Skip to main content
. Author manuscript; available in PMC: 2021 Feb 17.
Published in final edited form as: Chem Mater. 2020 May 27;32(12):5208–5216. doi: 10.1021/acs.chemmater.0c01307

Scheme 1.

Scheme 1.

Formation of the HA and Col-Based IPN; (a) Col was Modified with DBCO-sulfo-NHS and Azido-PEG5-NHS; Modified Cols were Then Mixed and Cross-linked via Bio-Orthogonal SPAAC under Physiological Conditions; Col SPAAC Click Gel is Denoted as xCol; (b) xHA was Formed by Cross-linking HA-SH and HA-MA via Thiol–Ene Click Reaction under Physiological Conditions; and (c) DBCO-modified Col, HA-SH, HA-MA, and Azido-Modified Col were Mixed in Order to Form the IPN under Physiological Conditions