Table 2.

Ongoing clinical trials using angiotensin-converting enzyme inhibitors (ACEIs) to inhibit the ACE/Ang-II/ATR1 axis of the renin–angiotensin system (RAS).

Study title	Phase	Interventions	Sponsor	ClinicalTrials.gov Identifier
Inhibition of the harmful arm of the RAS with ACEI
Ramipril for the Treatment of COVID-19 (RAMIC)	II	Ramipril vs. placebo	University of California, San Diego, USA	NCT04366050
Efficacy of Captopril in Covid-19 Patients with Severe Acute Respiratory Syndrome (SARS) CoV-2 Pneumonia (CAPTOCOVID)	II	Captopril vs. standard of care	Assistance Publique – Hôpitaux de Paris, France	NCT04355429
Angiotensin Converting Enzyme Inhibitors in Treatment of COVID 19	III	Captopril or enalapril vs. choloroquine	Tanta University, Egypt	NCT04345406