Table 4. Association between serum protein concentration and pulmonary function.
| Mid-childhood | Early-teen | ||||
|---|---|---|---|---|---|
| FEV1/FVCx100 β (95% CI) | BDR β (95% CI) | FEV1/FVCx100 β (95% CI) | BDR β (95% CI) | ||
| PGLYRP-1 Z-score* | |||||
| Univariate | 1.38 (0.15, 2.61) | 0.10 (−1.83, 2.03) | 1.45 (0.49, 2.42) | −0.68 (−1.54, 0.17) | |
| Model 1† | 1.12 (−0.18, 2.41) | 0.53 (−1.44, 2.51) | 1.05 (0.11, 1.98) | −0.49 (−1.40, 0.41) | |
| Model 2‡ | 1.38 (0.08, 2.69) | 0.61 (−1.40, 2.63) | 1.53 (0.54, 2.53) | −0.58 (−1.49, 0.34) | |
| Model 3# | 1.19 (−0.19, 2.56) | 1.00 (−1.04, 3.04) | 1.15 (0.20, 2.10) | −0.35 (−1.29, 0.59) | |
| sIL6Rα Z-score* | |||||
| Univariate | 0.95 (−0.31, 2.20) | −0.38 (−2.45, 1.69) | 0.11 (−0.86, 1.09) | 0.65 (−0.24, 1.54) | |
| Model 1† | 0.96 (−0.30, 2.21) | −0.37 (-2.41, 1.67) | 0.02 (−0.87, 0.92) | 0.71 (−0.19, 1.61) | |
| Model 2‡ | 0.88 (−0.40, 2.16) | −0.62 (−2.62, 1.39) | −0.02 (−1.00, 0.97) | 0.75 (−0.17, 1.66) | |
| Model 3# | 0.92 (−0.36, 2.20) | −0.11 (−0.96, 0.70) | −0.05 (−0.94, 0.85) | 0.79 (−0.12, 1.69) | |
*Serum protein concentrations were log10 transformed and converted into an internal Z-score.
†Serum protein concentrations were log10 transformed and converted into an internal Z-scoreupplemental Data\\Table 4_Association pulmonary outcomes.xlsx’ "Shed's race/ethnicity.
‡(Mother's demographics): adjusted for maternal pre-pregnancy BMI, maternal race/ethnicity, maternal level of education, maternal atopy, antibiotic exposure during pregnancy, smoking during pregnancy, 6 months or 1 year.
#Model 3 (all demographics and birth characteristics): adjusted for all demographics and characteristics in models 1 and 2 except maternal race/ethnicity. This the reported value in manuscript.