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. 2021 Feb 15;13(1):1880241. doi: 10.1080/19490976.2021.1880241

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Purine metabolism promotes barrier function. Hypoxanthine from the microbiota is salvaged for energy and nucleotide biosynthesis in the colon. This energy and nucleotide source fuels cytoskeletal support of the apical junction complex and drives mucin generation (AJC, apical junction complex; IMP, inosine monophosphate; Hpx, hypoxanthine; PRPP, phosphoribosyl pyrophosphate; ATP, adenosine triphosphate; GTP, guanosine triphosphate)