Figure 6.

RAGE⁺ T, NK, and NKT cells showed a significant increase in CD44 and PD-1 in livers of mice with NAFLD and HCC. a, Gating strategy to identify and characterize the phenotype of RAGE⁺ cells in NAFLD and HCC livers. b-e, Overview of receptors (CD44, PD-1) on (b) RAGE⁺ CD3⁺ CD8⁺ T, (c) RAGE⁺ CD3⁺ CD4⁺ T, (d) RAGE⁺ CD3⁻ NK1.1⁺ NK (e) RAGE⁺ CD3⁺ NK1.1⁺ NKT lymphocyte populations in livers of mice with NAFLD and HCC. Data were analyzed using unpaired student’s t-test. Shown are mean ± SEM, with n = 5–6 per group. *P < .05, **P < .01, ***P < .001