Figure 6.

Proposed mechanism of FA-induced decrease in p53 expression. FA decreases p53 expression at both the transcript and protein levels by inducing p53 promoter hypermethylation and decreasing m6A-p53 methylation levels. FA decreased m6A-p53 levels by decreasing METTL3 and METTL14; and suppressed expression of the m6A readers, YTHDF1, YTHDF3, and YTHDC2, which led to the decrease in p53 translation/protein expression. Furthermore, the decrease in p53 protein expression may be a consequence of the FA-induced decrease in p53 mRNA expression