Figure 7.

B. adolescentis ATCC15703 administration altered relative abundance of taxa at multiple levels in chronic colitis

A microbiome analysis was conducted using colorectal stool samples collected from 6 to 9 mice per group at day 36 in the PBS group and the B.a group with DSS. (a) Significant phyla alterations in the PBS group and the B.a group with DSS. (b) Bacteroidetes: Firmicutes (B: F) ratios in different groups. (c) Significant genus alterations in the PBS group and the B.a group with DSS. (d) Bacteria genomic DNA was extracted from mice colon tissue from the PBS group and the B.a group with DSS, genus Akkermansia level was tested by qPCR. (e,f) Pathways that are predicted to show significant different abundances between the PBS group and the B.a group with DSS according to the Kyoto Encyclopedia of Genes and Genome (KEGG) pathway analysis. n = 6–9. *p < .05, **p < .01(unpaired t test or Wilcoxon rank-sum test). PBS, phosphate buffered saline; B.a, Bifidobacterium adolescentis.