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. 2021 Feb 8;10(1):1880687. doi: 10.1080/2162402X.2021.1880687

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Evaluation of total zIgG4/-zIgE ratio and of total zIgG1/-zIgE ratio. Total IgG4, IgG1 and IgE levels of healthy donors, primary cancer patients and metastatic patients were measured. After z-normalization of all their values, we calculated the total zIgG4/-zIgE ratio in comparison with total zIgG1/-zIgE ratio. (a) Significantly higher values of total zIgG4/-zIgE ratio were found in metastatic compared to primary tumor patients (p = .0009433) and to healthy donors (p = .02474). (b) No significant differences were found when we evaluated the total zIgG1/-zIgE ratio. One-way ANOVA with Tukey post-hoc test was performed. n.s. P > .05, # P < .1, * P < .05, *** P < .001, **** P < .0001