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. 2021 Feb 8;10(1):1880687. doi: 10.1080/2162402X.2021.1880687

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Evaluation of IgG4 expression in CRC tumor site. (a) One representative immunohistochemistry staining of formalin fixed paraffin embedded colon cancer slides against IgG4 (brown spots). (b) Highlighted area in red was magnified and IgG4 (brown spots) are marked with white arrows. (c) Quantification of IgG4 cell positivity in ten different tumor slides. We found significantly more IgG4 positive cells in the stroma site than in the tumor site microenvironment (Paired two tails Student’s t test, p < .0001). (d) One representative IF staining of formalin fixed paraffin embedded colon cancer slides against CD38 positive B cells (green), against IgG4 (red), and against CD68 positive macrophages cells (white). (e) Highlighted area in red was magnified to show the close contact between CD38⁺ green B cell expressing IgG4 (red spots) and CD68⁺ (white) macrophages