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AUC Ratios of cytotoxicity versus TNFα when comparing CD3 affinity
| Cell line | CD3 Binder | Format | AUC |
||
|---|---|---|---|---|---|
| Cytotoxicity | TNFα | Ratio | |||
| T0 | CD3-H | DbFc | 369.1 | 759.8 | 0.5 |
| T0 | CD3-M | DbFc | 188.6 | 304.9 | 0.6 |
| T0 | CD3-L | DbFc | 35.1 | 0.0 | - |
| T2 | CD3-H | DbFc | 394.1 | 176.4 | 2.2 |
| T2 | CD3-M | DbFc | 188.0 | 103.3 | 1.8 |
| T2 | CD3-L | DbFc | 62.9 | 0.0 | |
| T0 | CD3-H | IgG | 330.6 | 161.0 | 2.1 |
| T0 | CD3-M | IgG | 206.0 | 84.8 | 2.4 |
| T2 | CD3-H | IgG | 268.0 | 0.0 | |
| T2 | CD3-M | IgG | 114.0 | 0.0 | |
