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Estimated parameters of the in vitro Cytotoxicity model for CD3 Bispecifics
| Parameter | DbFc Estimate (CV%) |
hIgG2dA Estimate (CV%) |
Description |
|---|---|---|---|
| kmax(1/hr) | 0.075 (20) | 0.11 (10) | Max. Tumor cell kill rate |
| Kc50Trimer*χ (#/nM) | 3.4e+05 (58) | 6.75e+06 (<1) | Half-maximal Trimer threshold for killing rate |
| nk | 0.7 (11) | 0.74 (6) | Hill-coefficient (steepness of killing curve) |
CV% = Coefficient of Variation for parameter estimates.
