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. 2020 Aug 13;13(5):515–523. doi: 10.1161/CIRCGEN.120.002919

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© 2020 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Association between LDL-C (low-density lipoprotein cholesterol) levels and LDL-C polygenic score percentile among individuals with familial hypercholesterolemia. The association between LDL-C levels and LDL-C polygenic score percentile is displayed for the (A) British Columbia Familial Hypercholesterolemia (BCFH), (B) Nutrition, Metabolism and Atherosclerosis Clinic (CNMA), and (C) UK Biobank cohorts. The blue lines and associated gray shading represent the linear regression line of best fit and 95% CI, respectively. D, A fixed-effect meta-analysis of the β coefficients and standard errors obtained from the linear regression models of LDL-C levels (mmol/L) vs continuous LDL-C polygenic score (per 20% increase) are shown. Linear regression models were adjusted for age and sex.