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. 2020 Aug 13;13(5):515–523. doi: 10.1161/CIRCGEN.120.002919

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© 2020 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Association between LDL-C (low-density lipoprotein cholesterol) levels and LDL-C polygenic score percentile among individuals with the same familial hypercholesterolemia (FH)-associated variant. The association between LDL-C levels and LDL-C polygenic score percentile is displayed for the individuals from the Nutrition, Metabolism and Atherosclerosis Clinic (CNMA) that were carriers for (A) the LDLR 15 kb promoter and exon 1 deletion and (B) the LDLR exon 3 missense variant p.Trp87Arg. The blue lines and associated grey shading represent the linear regression line of best fit and 95% CI, respectively.