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. 2020 Aug 13;13(5):515–523. doi: 10.1161/CIRCGEN.120.002919

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© 2020 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Association between risk of events and LDL-C (low-density lipoprotein cholesterol) polygenic score percentile among individuals with familial hypercholesterolemia. Atherosclerotic cardiovascular events included myocardial infarction, cardiovascular or carotid revascularization, and stroke. A, A fixed-effect meta-analyses of the β coefficients (ln[hazard ratio (HR)]) and SE obtained from Cox-proportional hazard models for risk of atherosclerotic cardiovascular events is shown for an LDL-C polygenic score ≥80th percentile score relative to and LDL-C polygenic score <80th percentile score. These Cox-proportional hazard models were adjusted for sex and used age as the time-to-event time scale. The studies included in the meta-analysis were the British Columbia Familial Hypercholesterolemia (BCFH), Nutrition, Metabolism and Atherosclerosis Clinic (CNMA), and UK Biobank cohorts. B, The time-to-atherosclerotic cardiovascular event curves are shown for the combined cohorts stratified by LDL-C polygenic score percentile above and below the 80th percentile. C, Sex-adjusted Cox-proportional hazard models are shown for the combined cohorts stratified by quintiles of LDL-C polygenic score percentile. ASCVD indicates atherosclerotic cardiovascular disease.