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. 2021 Feb 9;2021:6664453. doi: 10.1155/2021/6664453

Figure 4.

Figure 4

(a) The Venn Diagram analyses shows that LIUS-upregulated innatomic genes in three cell types are partially shared. The three genes shared by lymphoma cells (L) and preosteoblasts (P) and the 11 genes shared by lymphoma cells (L) and bone marrow cells (B) may be used for LIUS therapeutic markers. However, the majority of LIUS-upregulated innatomic genes are cell type specific. (b) The Venn Diagram analyses shows that the signaling pathways involved in LIUS-upregulated innatomic genes in three cell types are partially shared, such as metastasis signaling. In addition, three pathways are shared by LIUS-treated lymphoma cells and bone marrow cells including leukocyte extravasation, osteoarthritis pathway, and cardiac hypertrophy signaling. However, the majority of LIUS-upregulated innatomic pathways in lymphoma and bone marrow cells are cell type specific. (c) The Venn Diagram analyses shows that LIUS-downregulated innatomic genes in three cell types are not shared. The majority of LIUS-downregulated innatomic genes are cell type specific (L: lymphoma cells; B: bone marrow cells; P: preosteoblasts). (d) The Venn Diagram analysis shows that the signaling pathways involved in LIUS-downregulated innatomic genes in lymphoma cells and bone marrow cells are partially shared, such as metastasis signaling. However, the majority of LIUS-downregulated innatomic pathways in bone marrow cells are cell type specific.