(a) The Ingenuity Pathway Analyses (IPA) showed that three out of five subcellular localization groups (cytoplasm, extracellular space, and others) of LIUS-upregulated innatomic genes in lymphoma cells, preosteoblast cells, and bone marrow cells are significantly changed. However, none of the 14 functional groups of LIUS-upregulated innatomic genes in these three cell types were changed
| Classification type | Subset | Whole innate immunomic gene | Upregulated in lymphoma cells | Upregulated in preosteoblast cells | Upregulated in bone marrow cell | ||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Percentage | Number | Percentage | Number | Percentage | Number | Percentage | ||
| 5 subcellular locations | Cytoplasm∗,#,& | 481 | 34.96% | 14 | 18.18% | 2 | 9.52% | 38 | 35.19% |
| Extracellular space∗,# | 151 | 10.97% | 19 | 24.68% | 9 | 42.86% | 12 | 11.11% | |
| Nucleus | 405 | 29.43% | 21 | 27.27% | 9 | 42.86% | 34 | 31.48% | |
| Plasma membrane∗,& | 86 | 6.25% | 21 | 27.27% | 1 | 4.76% | 21 | 19.44% | |
| Other∗,& | 253 | 18.39% | 2 | 2.60% | 1 | 4.76% | 3 | 2.78% | |
|
| |||||||||
| 14 functional types | Cytokine | 53 | 3.85% | 6 | 7.79% | 0 | 0.00% | 2 | 1.85% |
| Enzyme | 232 | 16.86% | 6 | 7.79% | 1 | 4.76% | 18 | 16.67% | |
| G-protein-coupled receptor | 22 | 1.60% | 2 | 2.60% | 0 | 0.00% | 0 | 0.00% | |
| Growth factor | 21 | 1.53% | 2 | 2.60% | 1 | 4.76% | 1 | 0.93% | |
| Ion channel | 8 | 0.58% | 0 | 0.00% | 0 | 0.00% | 1 | 0.93% | |
| Kinase | 113 | 8.21% | 6 | 7.79% | 1 | 4.76% | 11 | 10.19% | |
| Ligand-dependent nuclear receptor# | 6 | 0.44% | 2 | 2.60% | 1 | 4.76% | 0 | 0.00% | |
| Other | 459 | 33.36% | 22 | 28.57% | 7 | 33.33% | 43 | 39.81% | |
| Peptidases | 54 | 3.92% | 4 | 5.19% | 3 | 14.29% | 3 | 2.78% | |
| Phosphatase | 22 | 1.60% | 1 | 1.30% | 0 | 0.00% | 1 | 0.93% | |
| Transcription regulator | 229 | 16.64% | 15 | 19.48% | 6 | 28.57% | 19 | 17.59% | |
| Translation regulator | 10 | 0.73% | 0 | 0.00% | 0 | 0.00% | 1 | 0.93% | |
| Transmembrane receptor | 88 | 6.40% | 7 | 9.09% | 0 | 0.00% | 3 | 2.78% | |
| Transporter | 59 | 4.29% | 4 | 5.19% | 1 | 4.76% | 5 | 4.63% | |
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| |||||||||
| Total | 1376 | 77 | 21 | 108 | |||||
∗ P value of comparison between whole innate immunity genes and upregulated gene in lymphoma cell dataset <0.05. #P value of comparison between whole innate immunity genes and upregulated gene in preosteoblast cell dataset <0.05. &P value of comparison between whole innate immunity genes and upregulated gene in bone marrow cell dataset <0.05.