(b) The Ingenuity Pathway Analyses (IPA) show that two out of five subcellular localization groups (nucleus and plasma membrane) of LIUS-downregulated innatomic genes in lymphoma cells, preosteoblasts, and bone marrow cells are significantly changed. However, one of the 14 functional groups (phosphatase) of LIUS-downregulated innatomic genes in these three cell types are changed
| Classification type | Subset | Whole innate immunity gene | Downregulated in lymphoma cells | Downregulated in preosteoblast cells | Downregulated in bone marrow cells | ||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Percentage | Number | Percentage | Number | Percentage | Number | Percentage | ||
| Subcellular location -5 |
Cytoplasm | 481 | 34.96% | 12 | 30.77% | 6 | 35.29% | 67 | 36.81% |
| Extracellular space | 151 | 10.97% | 6 | 15.38% | 3 | 17.65% | 24 | 13.19% | |
| Nucleus& | 405 | 29.43% | 11 | 28.21% | 4 | 23.53% | 32 | 17.58% | |
| Plasma membrane∗,& | 86 | 6.25% | 10 | 25.64% | 4 | 23.53% | 49 | 26.92% | |
| Other∗,& | 253 | 18.39% | 0 | 0.00% | 0 | 0.00% | 10 | 5.49% | |
|
| |||||||||
| Functional type -14 |
Cytokine | 53 | 3.85% | 2 | 5.13% | 2 | 11.76% | 13 | 7.14% |
| Enzyme | 232 | 16.86% | 5 | 12.82% | 1 | 5.88% | 26 | 14.29% | |
| G-protein-coupled receptor | 22 | 1.60% | 1 | 2.56% | 0 | 0.00% | 6 | 3.30% | |
| Growth factor | 21 | 1.53% | 1 | 2.56% | 0 | 0.00% | 2 | 1.10% | |
| Ion channel | 8 | 0.58% | 1 | 2.56% | 0 | 0.00% | 0 | 0.00% | |
| Kinase | 113 | 8.21% | 2 | 5.13% | 0 | 0.00% | 20 | 10.99% | |
| Ligand-dependent nuclear receptor | 6 | 0.44% | 0.00% | 0 | 0.00% | 1 | 0.55% | ||
| Other | 459 | 33.36% | 12 | 30.77% | 7 | 41.18% | 50 | 27.47% | |
| Peptidases | 54 | 3.92% | 0.00% | 0 | 0.00% | 8 | 4.40% | ||
| Phosphatase∗,& | 22 | 1.60% | 3 | 7.69% | 0 | 0.00% | 7 | 3.85% | |
| Transcription regulator | 229 | 16.64% | 6 | 15.38% | 4 | 23.53% | 20 | 10.99% | |
| Translation regulator | 10 | 0.73% | 1 | 2.56% | 0 | 0.00% | 0 | 0.00% | |
| Transmembrane receptor | 88 | 6.40% | 4 | 10.26% | 2 | 11.76% | 21 | 11.54% | |
| Transporter | 59 | 4.29% | 1 | 2.56% | 1 | 5.88% | 8 | 4.40% | |
|
| |||||||||
| Total | 1376 | 39 | 17 | 182 | |||||
∗ P value of comparison between whole innate immunity genes and downregulated gene in lymphocyte dataset <0.05. #P value of comparison between whole innate immunity genes and downregulated gene in protoplast dataset <0.05. &P value of comparison between whole innate immunity genes and downregulated gene in bone marrow cell dataset <0.05.