Figure 10.

Administration of sRAGE attenuates sepsis-associated acute lung injury. Mice were subjected to CLP or sham surgery. Recombinant sRAGE protein (200 μg/kg) was intratracheally injected immediately before the onset of sepsis, with an equivalent volume of saline intratracheally injected in other groups. (a) Cell count and (b) protein concentration in BAL fluid. Histopathological examination using hematoxylin and eosin staining (c). Original magnification, ×200. Scale bars correspond to 50 μm. The severity of lung injury was scored by a pathologist blinded to group allocation (d). Data are presented as the mean ± SEM (n = 7). ^∗p < 0.05 and ^∗∗p < 0.01 vs. the sham group; ^#p < 0.05 and ^##p < 0.01 vs. the CLP group.