Figure 6.

The effect of autophagy on liver regeneration in the aged individual. Liver resection and aging lead to mitochondrial dysfunction. Autophagy can degrade dysfunctional mitochondria and other cellular components to promote the synthesis of new organelles and energy production, thereby facilitating liver regeneration. However, the induction of autophagy through the mTOR pathway impedes cell proliferation. Therefore, inducing autophagy via the mTOR-independent pathway is more appropriate for promoting liver regeneration.