Table 1.

Association of m⁶A modification core genes and glioma risk in Southern Chinese children

Gene	Polymorphism	Allele		Case (n = 171)			Control (n = 228)			AOR (95% CI)a	pa	AOR (95% CI)b	pb	HWE
		A	B	AA	AB	BB	AA	AB	BB
ALKBH5	rs1378602	G	A	139	30	2	182	43	2	0.97 (0.58–1.63)	0.920	1.27 (0.17–9.21)	0.815	0.757
ALKBH5	rs8400	G	A	51	85	35	71	118	38	1.14 (0.74–1.77)	0.548	1.37 (0.82–2.31)	0.233	0.350
METTL3	rs1061026	T	G	141	28	2	187	37	4	0.98 (0.58–1.65)	0.935	0.66 (0.12–3.74)	0.641	0.185
METTL3	rs1061027	C	A	112	55	4	139	79	10	0.80 (0.53–1.22)	0.295	0.55 (0.17–1.79)	0.317	0.771
METTL3	rs1139130	A	G	62	85	24	91	102	35	1.13 (0.75–1.71)	0.559	0.88 (0.50–1.56)	0.665	0.470
METTL3	rs1263801	G	C	91	67	13	112	90	26	0.83 (0.55–1.23)	0.349	0.66 (0.33–1.33)	0.241	0.230
METTL14	rs1064034	T	A	77	83	11	112	97	19	1.23 (0.82–1.84)	0.316	0.82 (0.38–1.77)	0.605	0.755
METTL14	rs298982	G	A	135	36	0	179	46	3	1.02 (0.63–1.67)	0.930	–	–	0.982
METTL14	rs62328061	A	G	106	63	2	154	66	8	1.29 (0.85–1.97)	0.232	0.33 (0.07–1.59)	0.168	0.778
METTL14	rs9884978	G	A	110	53	8	155	62	11	1.14 (0.75–1.75)	0.534	0.91 (0.35–2.35)	0.848	0.150
METTL14	rs4834698	T	C	45	81	45	51	118	59	0.79 (0.49–1.25)	0.313	1.03 (0.65–1.63)	0.892	0.583
WTAP	rs9457712	G	A	116	51	4	148	71	9	0.86 (0.56–1.32)	0.487	0.58 (0.17–1.95)	0.381	0.894
WTAP	rs1853259	A	G	57	85	29	62	120	46	0.74 (0.48–1.14)	0.168	0.77 (0.45–1.29)	0.314	0.382
WTAP	rs7766006	G	T	57	88	26	97	106	25	1.58 (1.04–2.40)c	0.034c	1.46 (0.81–2.65)	0.211	0.620
YTHDC1	rs2293596	T	C	108	55	8	140	76	12	0.91 (0.60–1.38)	0.668	0.84 (0.33–2.12)	0.708	0.689
YTHDC1	rs2293595	T	C	77	74	20	74	112	42	0.59 (0.39–0.90)c	0.013c	0.61 (0.34–1.08)	0.091	0.974
YTHDC1	rs3813832	T	C	109	53	9	115	96	17	0.61 (0.40–0.91)c	0.016c	0.72 (0.31–1.67)	0.448	0.619
YTHDF1	rs6011668	C	T	132	32	7	168	56	4	0.81 (0.50–1.29)	0.369	2.66 (0.75–9.43)	0.131	0.787
YTHDF1	rs6090311	A	G	61	75	35	92	103	33	1.20 (0.79–1.81)	0.400	1.58 (0.93–2.68)	0.093	0.633
YTHDF2	rs3738067	A	G	83	78	10	144	74	10	1.86 (1.24–2.80)c	0.003c	1.31 (0.53–3.25)	0.560	0.900
FTO	rs1477196	G	A	105	58	8	127	87	14	0.76 (0.51–1.15)	0.193	0.80 (0.32–1.96)	0.617	0.860
FTO	rs9939609	T	A	129	33	9	175	51	2	1.07 (0.67–1.72)	0.757	7.39 (1.56–35.11)c	0.012c	0.411
FTO	rs7206790	C	G	110	53	8	165	59	4	1.45 (0.94–2.24)	0.090	2.73 (0.80–9.38)	0.110	0.626
FTO	rs8047395	A	G	75	78	18	75	116	37	0.63 (0.41–0.95)c	0.026c	0.63 (0.34–1.16)	0.139	0.481

AOR, adjusted odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium.

^aAdjusted for age and gender for dominant model.

^bAdjusted for age and gender for recessive model.

^cSignificant results.