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. 2021 Jan 5;20:199–208. doi: 10.1016/j.omto.2020.12.013

Table 4.

Stratification analysis between YTHDF2 rs3738067 A > G polymorphism and glioma risk

Variables rs3738067 (cases/controls) Crude OR p AOR (95% CI)a pa
AA AG/GG (95% CI)

Age, months

<60 39/73 46/46 1.87 (1.07–3.29)b 0.029b 1.87 (1.06–3.29)b 0.030b
≥60 44/71 42/38 1.78 (1.00–3.18) 0.050 1.81 (1.01–3.23)b 0.046b

Gender

Females 38/61 43/32 2.16 (1.17–3.97)b 0.014b 2.27 (1.22–4.25)b 0.010b
Males 45/83 45/52 1.60 (0.93–2.74) 0.089 1.61 (0.93–2.77) 0.087

Subtypes

Astrocytic tumors 61/144 64/84 1.80 (1.16–2.80)b 0.009b 1.90 (1.20–2.99)b 0.006b
Ependymoma 13/144 12/84 1.58 (0.69–3.63) 0.278 1.58 (0.68–3.64) 0.287
Neuronal and mixed 7/144 7/84 1.71 (0.58–5.06) 0.329 1.63 (0.55–4.84) 0.381
Embryonal tumors 2/144 5/84 4.29 (0.81–22.58) 0.086 6.82 (1.00–46.76) 0.051

Tumor grades

I 52/144 51/84 1.68 (1.05–2.69)b 0.031b 1.78 (1.10–2.89)b 0.018b
II 14/144 14/84 1.71 (0.78–3.77) 0.180 1.71 (0.78–3.77) 0.182
III 8/144 7/84 1.50 (0.53–4.29) 0.449 1.47 (0.51–4.23) 0.475
IV 9/144 16/84 3.05 (1.29–7.20)b 0.011b 3.08 (1.23–7.71)b 0.016b
I+II 66/144 65/84 1.69 (1.09–2.61)b 0.018b 1.77 (1.14–2.75)b 0.012b
III+IV 17/144 23/84 2.32 (1.17–4.59)b 0.016b 2.29 (1.14–4.60)b 0.019b

AOR, adjusted odds ratio; CI, confidence interval.

a

Adjusted for age and gender, omitting the corresponding stratify factor.

b

Significant results.