TABLE 2.
Susceptibility of S. enterica serovar Typhimurium to several AGA and β-lactam antibiotics.
| Strain |
MICs (μg/mL) |
|||||||
| AMK | NET | STR | KAN | CEP | CXM | CRO | CTX | |
| JS | 2 | 0.25 | 16 | 2 | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxA | 8 | 0.5 | 32 | 8 | 32 | 16 | 0.25 | 0.25 |
| JSΔcpxA-CL | 2 | 0.25 | 16 | 2 | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxR | 0.5 | 0.0625 | 2 | 1 | 2 | 2 | 0.03125 | 0.03125 |
| JSΔcpxRA | 0.5 | 0.0625 | 2 | 1 | 2 | 2 | 0.03125 | 0.03125 |
| JSΔacka-pta | 4 | 0.25 | 16 | 4 | 2 | 4 | 0.125 | 0.03125 |
| JSΔcpxAΔacka-pta | 4 | 0.25 | 16 | 4 | 2 | 4 | 0.125 | 0.03125 |
| JScpxRD51A | 1 | 0.0625 | 4 | 1 | 2 | 2 | 0.03125 | 0.03125 |
| JScpxRM199A | 2 | 0.25 | 16 | 2 | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxARD51A | 2 | 0.125 | 8 | 1 | 2 | 2 | 0.03125 | 0.03125 |
| JSΔcpxARM199A | 2 | 0.125 | 8 | 1 | 2 | 4 | 0.0625 | 0.0625 |
| JScpxA38 | 8 | 0.5 | 32 | 8 | 32 | 16 | 0.25 | 0.25 |
| JScpxA92–104 | 8 | 0.5 | 32 | 8 | 32 | 16 | 0.25 | 0.25 |
| JScpxA38-CL | 2 | 0.25 | 16 | 2 | 4 | 4 | 0.0625 | 0.0625 |
| JScpxA92–104-CL | 2 | 0.25 | 16 | 2 | 4 | 4 | 0.0625 | 0.0625 |
| JScpxA38ΔcpxR:Kan | 0.5 | 0.0625 | 2 | – | 2 | 2 | 0.03125 | 0.03125 |
| JScpxA92–104ΔcpxR:Kan | 0.5 | 0.0625 | 2 | – | 2 | 2 | 0.03125 | 0.03125 |
| JSΔacrB | 0.5 | 0.25 | 4 | 2 | 0.5 | 0.125 | 0.0625 | 0.03125 |
| JSΔacrB-CL | 2 | 0.25 | 16 | 2 | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxAΔacrB | 2 | 1 | 16 | 8 | 1 | 0.5 | 0.25 | 0.0625 |
| JScpxA38ΔacrB | 4 | 0.5 | 16 | 8 | 1 | 0.25 | 0.25 | 0.125 |
| JScpxA92–104ΔacrB | 4 | 1 | 16 | 8 | 1 | 0.25 | 0.25 | 0.125 |
| JSΔcpxRΔacrB | 0.125 | 0.0625 | 2 | 1 | 0.5 | 0.0625 | 0.03125 | 0.0157 |
| JSΔtolC | 0.5 | 0.25 | 4 | 1 | 0.5 | 0.125 | 0.0625 | 0.03125 |
| JSΔtolC-CL | 2 | 0.25 | 16 | 2 | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxAΔtolC | 2 | 0.5 | 16 | 8 | 1 | 0.25 | 0.25 | 0.0625 |
| JScpxA38ΔtolC | 4 | 1 | 16 | 4 | 1 | 0.25 | 0.25 | 0.625 |
| JScpxA92–104ΔtolC | 2 | 1 | 16 | 4 | 1 | 0.25 | 0.5 | 0.125 |
| JSΔcpxRΔtolC | 0.125 | 0.03125 | 1 | 0.5 | 0.5 | 0.0625 | 0.03125 | 0.0157 |
| JSΔramA::Kan | 2 | 0.25 | 16 | – | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxAΔramA::Kan | 8 | 0.5 | 32 | – | 16 | 8 | 0.125 | 0.125 |
| JSΔstm3031::Kan | 2 | 0.25 | 16 | – | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxAΔstm3031::Kan | 8 | 0.5 | 32 | – | 32 | 16 | 0.25 | 0.25 |
| JSΔhtpX::Kan | 2 | 0.25 | 16 | – | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxAΔhtpX::Kan | 8 | 0.5 | 32 | – | 32 | 16 | 0.25 | 0.25 |
| JSΔspy::Kan | 2 | 0.25 | 16 | – | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxAΔspy::Kan | 8 | 0.5 | 32 | – | 32 | 16 | 0.25 | 0.25 |
| JSΔacrD::Kan | 2 | 0.25 | 16 | – | 4 | 4 | 0.0625 | 0.0625 |
| JSΔcpxAΔacrD::Kan | 8 | 0.5 | 32 | – | 32 | 16 | 0.25 | 0.25 |
| JSΔacrBΔacrD::Kan | 0.5 | 0.25 | 4 | – | 0.5 | 0.125 | 0.0625 | 0.03125 |
| JSΔcpxAΔacrBΔacrD::Kan | 2 | 1 | 16 | – | 1 | 0.5 | 0.25 | 0.0625 |
AMK, amikacin; NET, netilmicin; STR, streptomycin; KAN, kanamycin; CEP, Cefalotin; CXM, cefuroxime; CRO, ceftriaxone; CTX, cefotaxime.