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. 2021 Feb 4;11:613745. doi: 10.3389/fimmu.2020.613745

Figure 4.

Figure 4

The absolute number of ASC-speck+ monocytes predicted the 90-days survival of sepsis patients. (A) Patients with a higher absolute number of ASC-specks on day 6 have a favorable outcome within 90 days *p < 0.05. Healthy donors n = 19; sepsis patients (survivors) day 1 n = 17, day 2 n = 17, day 3 n = 16, day 4 n = 14, day 5 n = 11, day 6 n = 12, day 7 n = 10; sepsis patients (non-survivors) day 1 n = 7, day 2 n = n = 7, day 3 n = 6, day 4 n = 6, day 5 n = 6, day 6 n = 6, day 7 n = 6. (B) Receiver operating characteristic (ROC) curve analysis on day 6 showed the AUROC for the absolute number of ASC-speck+ monocytes predicting survival was 0.875 (p = 0.011, 95% confidence interval (CI): 0.699–1.051) and the best the cutoff value was 1650 cells/ml with the highest sensitivity (83.33%) and specificity (83.33%). (C) Kaplan-Meier analysis revealed that patients with higher levels of ASC-speck positive monocytes (>1650 cells/ml) on day 6 have better survival [p = 0.0079, hazard ratio (HR) = 10.23, 95% CI: 1.840–56.94]. The patient cohort included 11 survivors and 7 non-survivors.