Table 3.

Grade 3 and 4 of adverse events stratified by the initial dose of irinotecan in the first cycle of treatment

Variable, n (%), (n = 31)	Initial dose of irinotecan in the first cycle of treatment
	≥ 150 mg/m2	120 mg/m2	90–100 mg/m2	70–80 mg/m2	≤ 60 mg/m2
Neutropenia	4 (67)	1 (20)	3 (27)	1 (20)	0
Thrombocytopenia	0	0	0	0	0
Febrile neutropenia	1 (17)	0	2 (18)	1 (20)	0
Diarrhea	0	0	2 (18)	0	0
Anorexia	2 (33)	0	2 (18)	0	1 (25)
Fatigue	1 (17)	1 (20)	0	0	0
Nausea	0	0	1 (9)	0	0
Vomiting	0	0	1 (9)	0	0
Peripheral neuropathy	0	0	1 (9)	0	1 (25)