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. 2021 Jan 20;38(2):1328–1341. doi: 10.1007/s12325-020-01601-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Time-point analyses. Mean change from baseline in a heart rate, b PR interval, c QRS duration, and d QTcF interval. Values are means ± 90% CIs; estimates and CIs are model based. PR interval time from onset of P wave to the start of the QRS complex, QRS duration interval of time between Q wave and S wave, QTcF interval QT interval corrected for heart rate using Fridericia’s formula, CI confidence interval, IV intravenously, bpm beats per minute, C Cycle, D Dose