Figure 4.

Higher visual areas were more active during expert task performance

(A) Activation maps for individual animals on day 1 of training (top row), when animals were naive, versus day 9 of training (bottom row), when animals performed the task expertly, calculated using the normalized activity difference for task-on minus task-off periods. Each map has been registered to the Allen Brain Atlas (overlaid) using stereotaxic marks. Control regions are shown as slightly larger than they actually were for better visibility.

(B) Activation maps during task performance on day 1, day 9, and during passive playback of a previous session (representing the normalized activity difference for task-on minus task-off periods). Each map has been registered to the Allen Brain Atlas by stereotaxic marks and then averaged across 7 mice.

(C) The relative ratio of task activation in higher visual areas versus V1 increased over training. When animals passively viewed playback of the same session, higher visual areas were less active. Red bars indicate mean ratios (n = 7 mice, paired t test, Bonferroni corrected).