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. 2021 Feb 4;12:630852. doi: 10.3389/fmicb.2021.630852

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Copyright © 2021 Piscione, Mazzone, Di Marcantonio, Muraro and Mincione.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multistep model for progression of gastric cancer, based on stimuli and mechanisms (right and left) interacting with the histopathologic Correa Cascade (center), from superficial gastritis to carcinoma (adapted from Fox and Wang, 2001).