Table 2.
Overview of tested OMV types for Neisseria meningitidis and Bordetella pertussis and their results.
| Bacterium | OMV type | Modifications | Results | Remarks |
|---|---|---|---|---|
| Neisseria meningitidis | dOMVs | None | 80–87% effectiveness | Clonal outbreaks |
| ngOMVs | ΔrmpM, ΔlpxL1 | 79% effectiveness | 41–82% cross-reactivity | |
| Bordetella pertussis | lgOMVs | PagL | 5-fold decrease in bacterial colonization | Compared to naïve mice |
| nOMVs | None | 5-fold decrease in bacterial colonization | Compared to naïve mice | |
| sOMVs | None | 5-fold decrease in bacterial colonization | Compared to naïve mice at day 63 |
Neisseria meningitidis OMVs results are obtained in humans (Holst et al., 2009, 2013; Keiser et al., 2011), Bordetella pertussis OMV results are obtained from mice experiments (Roberts et al., 2008; Asensio et al., 2011; Raeven et al., 2016).