Table 3.
Metabolites significantly decreased in Women relative to Men over time.
| Metabolite | P-value | Bonferroni corrected P-value | − log10p | β coefficient | Super pathway | Sub pathway |
|---|---|---|---|---|---|---|
| N-acetylvaline | 2.55 E−05 | 1.47 E−02 | 4.59 | − 0.10 | Amino acid | Leucine, isoleucine and valine metabolism |
| N-acetylleucine | 7.65 E−06 | 4.42 E−03 | 5.12 | − 0.12 | Amino acid | Leucine, isoleucine and valine metabolism |
| Alpha-hydroxyisocaproate | 9.27 E−07 | 5.36 E−04 | 6.03 | − 0.13 | Amino acid | Leucine, isoleucine and valine metabolism |
| 3-hydroxyisobutyrate | 1.37 E−06 | 7.90 E−04 | 5.86 | − 0.13 | amino acid | Leucine, isoleucine and valine metabolism |
| 3-hydroxy-2-ethylpropionate | 2.06 E−09 | 1.19 E−06 | 8.69 | − 0.15 | Amino acid | Leucine, isoleucine and valine metabolism |
| 2-hydroxy-3-methylvalerate | 5.00 E−08 | 2.89 E−05 | 7.30 | − 0.16 | Amino acid | Leucine, isoleucine and valine metabolism |
| 2,3-dihydroxy-2-methylbutyrate | 4.77 E−07 | 2.76 E−04 | 6.32 | − 0.17 | Amino acid | Leucine, isoleucine and valine metabolism |
| Beta-hydroxyisovalerate | 4.04 E−12 | 2.33 E−09 | 11.39 | -0.19 | Amino acid | Leucine, isoleucine and valine metabolism |
| Glycochenodeoxycholate | 1.59 E−06 | 9.18 E−04 | 5.80 | − 0.20 | Lipid | Primary bile acid metabolism |
| Taurocholate | 4.19 E−05 | 2.42 E−02 | 4.38 | − 0.21 | Lipid | Primary bile acid metabolism |
| Glycochenodeoxycholate glucuronide | 2.94 E−12 | 1.70 E−09 | 11.53 | − 0.28 | Lipid | Primary bile acid metabolism |
| Taurochenodeoxycholate | 2.20 E−08 | 1.27 E−05 | 7.66 | − 0.28 | Lipid | Primary bile acid metabolism |
| Glycochenodeoxycholate sulfate | 4.26 E−11 | 2.46 E−08 | 10.37 | − 0.32 | Lipid | Primary bile acid metabolism |
| Glycodeoxycholate sulfate | 4.01 E−06 | 2.32 E−03 | 5.40 | − 0.23 | Lipid | Secondary bile acid metabolism |
| Glycolithocholate sulfate | 5.82 E−09 | 3.36 E−06 | 8.24 | − 0.27 | Lipid | Secondary bile acid metabolism |
| Glycocholenate sulfate | 6.22 E−14 | 3.59 E−11 | 13.21 | − 0.28 | Lipid | Secondary bile acid metabolism |
| Taurolithocholate 3-sulfate | 3.11 E−12 | 1.80 E−09 | 11.51 | − 0.34 | Lipid | Secondary bile acid metabolism |
| Taurocholenate sulfate | 1.03 E−16 | 5.94 E−14 | 15.99 | − 0.38 | Lipid | Secondary bile acid metabolism |
Significant results presented following mixed-effects modeling of each of the 578 individual metabolites measured at day 0, 3 and 7. All estimates adjusted for age, SAPS II, admission diagnosis, 25(OH)D at day 0, absolute change in 25(OH)D level at day 3 and plasma day (as the random-intercept). A multiple test-corrected threshold of P-value < 8.65 × 10–5 was used to identify all significant associations. Negative β coefficient values indicate lower abundance in females relative to males.