Table 1.
Baseline demographic characteristics of control and cases (n = 378).
| NCI (n = 80) |
CIND (n = 158) |
Dementia (n = 140) |
p-value | |
|---|---|---|---|---|
| Age, mean (SD), year | 68.8 (6.3) | 72.0 (8.2)* | 75.7 (7.8)*† | < 0.01 |
| Female, n (%) | 41 (51.2) | 79 (50.0) | 86 (61.4) | 0.11 |
| Education ≤ elementary, n (%) | 24 (30.0) | 79 (50.0)* | 98 (70.0)*† | < 0.01 |
| Hypertension, n (%) | 45 (56.3) | 108 (68.4) | 118 (84.3)*† | < 0.01 |
| Diabetes, n (%) | 18 (22.5) | 54 (34.2) | 62 (44.3)* | 0.01 |
| Cardiovascular disease, n (%) | 4 (5.0) | 19 (12.0) | 26 (18.6)* | 0.01 |
| Hyperlipidemia, n (%) | 54 (67.5) | 120 (75.9) | 109 (77.9) | 0.22 |
| APOE ε4 carrier, n (%) | 14 (17.5) | 47 (29.7) | 45 (32.1) | 0.06 |
| Osteopontin, median (IQR), ng/ml | 59.4 (22.1) | 65.0 (28.4) | 81.8 (42.2)*† | < 0.01 |
Bold values indicates p < 0.05 using ANOVA or Chi-square tests.
CIND, cognitive impairment no dementia; IQR, interquartile range; n, number; NCI, non-cognitive impairment; SD, standard deviation.
*Significantly different from NCI (post-hoc test, p < 0.05).
†Significantly different from CIND (post-hoc test, p < 0.05).