Table 3.

Association between osteopontin and cognitive impairment stratified by presence of significant cerebrovascular disease (CeVD), expressed in odds ratios (OR) and 95% confidence interval (CI).

Osteopontin	Significant cerebrovascular disease (CeVD)
	Absence		Presence
	CIND without CeVD (n = 79) OR (95% CI)a	AD without CeVD (n = 40) OR (95% CI)a	CIND with CeVD (n = 79) OR (95% CI)a	AD with CeVD (n = 69) OR (95% CI)a	VaD (n = 31) OR (95% CI)a,b
1st tertile	1	1	1	1	1
2nd tertile	0.5 (0.2–1.0)	1.1 (0.2–5.9)	1.3 (0.6–3.0)	1.2 (0.4–3.6)	3.3 (0.8–41.7)
3rd tertile	1.5 (0.6–3.9)	15.3 (3.2–73.6)	3.1 (1.1–8.5)	5.1 (1.5–16.6)	8.6 (1.8–41.7)

Bold values indicates p < 0.05 using binary logistic regression.

Abbreviations: CeVD, cerebrovascular disease; CIND, cognitive impairment no dementia; AD, Alzheimer’s disease; VaD, vascular dementia; OR, odds ratio; CI, confidence interval.

^aAdjusted for age, education, hypertension, diabetes and cardiovascular disease.

^bEstimated using Firth logistic regression due to separation where hypertension perfectly predicts VaD.