Table 4.
Association between osteopontin and markers of cerebrovascular disease (CeVD), expressed in risk ratios (RR) or mean differences (MD) and the respective 95% confidence interval (CI).
| WMH by ARWMC scores MD (95% CI) |
Number of cortical infarcts RR (95% CI) |
Number of lacunes RR (95% CI) |
|
|---|---|---|---|
| Osteopontina | |||
| All subjects (max n = 378) | |||
| Model Ib | 5.6 (2.9–8.4) | 4.8 (1.4–17.4) | 3.5 (1.6–7.8) |
| Model IIb | 4.4 (1.7–7.1)c | 3.3 (0.9–12.7)d | 1.5 (0.6–3.6)e |
| Cognitive impairment groups (max n = 298) | |||
| Model Ib | 4.6 (1.3–7.7) | 4.2 (1.1–15.8) | 2.3 (1.0–5.1) |
| Model IIb | 3.9 (0.8–6.9)c | 3.2 (0.8–12.7)d | 1.2 (0.5–2.8)e |
Bold values indicates p < 0.05 using Poisson or linear regression.
CeVD, cerebrovascular disease; WMH, white matter hyperintensities; ARWMC, age-related white matter changes; max n, maximum number; RR, risk ratio; MD, mean difference; CI, confidence interval.
aLog-transformed.
bAdjusted for age, gender, APOE ε4 carrier, hypertension, hyperlipidemia, cardiovascular disease, and additionally for c cortical infarct and lacunes, d WMH and lacunes, or e WMH and cortical infarct.