Table 5.

Association between osteopontin and brain atrophy, expressed in odds ratios (OR) and 95% confidence interval (CI).

	Central atrophy OR (95% CI)b	Cortical atrophy OR (95% CI)b	Medial temporal atrophy OR (95% CI)b
Osteopontina
All subjects (max n = 377)	22.2 (4.3–114.3)	46.4 (6.6–328.1)	49.3 (9.2–263.9)
Cognitive impairment groups (max n = 297)	17.9 (3.2–100.8)	18.3 (2.3–146.2)	26.6 (4.6–155.2)

Bold values indicates p < 0.05 using binary logistic regression.

CeVD, cerebrovascular disease; WMH, white matter hyperintensities; ARWMC, age-related white matter changes; max n, maximum number; OR, odds ratio; CI, confidence interval.

^aLog-transformed.

^bAdjusted for age, gender, education, hypertension, diabetes and heart disease.