. 2021 Feb 17;11:4010. doi: 10.1038/s41598-021-83601-6

Table 7.

Associations between osteopontin and inflammatory markers, expressed in mean difference (MD) and 95% confidence interval (CI).

	IL-6^a MD (95% CI)^b	IL-8^a MD (95% CI)^b	TNF^a MD (95% CI)^b
Osteopontin^a
All subjects (max n = 376)	0.9 (0.5–1.2)	0.3 (0.1–0.4)	0.3 (0.1–0.5)
Cognitive impairment (max n = 297)	0.9 (0.5–1.3)	0.3 (0.1–0.5)	0.3 (0.1–0.4)

IL-6^a
MD (95% CI)^b

IL-8^a
MD (95% CI)^b

TNF^a
MD (95% CI)^b

Osteopontin^a

All subjects

(max n = 376)

0.9 (0.5–1.2)

0.3 (0.1–0.4)

0.3 (0.1–0.5)

Cognitive impairment (max n = 297)

0.9 (0.5–1.3)

0.3 (0.1–0.5)

0.3 (0.1–0.4)

Bold values indicates p < 0.05 using linear regression.

IL-6, interleukin-6; IL-8, interleukin-8; TNF, tumor necrosis factor; NCI, non-cognitive impairment; CIND, cognitive impairment no dementia; max n, maximum number; MD, mean difference; CI, confidence interval.

^aLog-transformed.

^bAdjusted for age, hypertension, hyperlipidemia, diabetes and cardiovascular disease.