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. 2021 Feb 18;6:68. doi: 10.1038/s41392-020-00444-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — m⁶A modification regulates protein translation. The m⁶A modification is catalyzed by the writers (METTL3/METTL14/WTAP, WETTL16) and demethylated by erasers (FTO, ALKBH5). The m⁶A modification is recognized by the readers (YTHDF1/2/3, YTHDC1/2, IGF2BP1/2/3, and HuR). The translation procedure of target genes can be influenced by the m6A modification level