Table 2.
Noncoding RNAs involved in translation regulation
| Protein | Clinical correlates in cancers | Ref. | |
|---|---|---|---|
| microRNA | |||
| miR-10b | inhibits HOXD10 translation | promotes the migration and invasion of breast cancer | 54 |
| miR-12528 | inhibits IGF1R translation | inhibits cell proliferation and metastasis in lung cancer | 55 |
| miR-146a | inhibits c-met translation | inhibits colorectal cancer liver metastasis | 56 |
| miR-125b | inhibits PIGF translation | inhibits the angiogenesis of liver cancer | 57 |
| miR-143-3p | inhibits BRD2 translation | increases the therapy sensitivity to cisplatin in gastric cancer | 58 |
| miR-648 | inhibits MGMT translation | sensitizes gliomas to temozolomide treatment | 59 |
| miR-675-5p | inhibits TP53 translation | promotes the development of colorectal cancer | 60 |
| miR-10a | promotes RP translation | promotes the overall protein translation | 61 |
| microRNA&RBP | |||
| miR-143 and MSI2 | regulates KRAS protein translation | affects the tumor growth of bladder cancer | 62 |
| miR-155-5p and HuR | promotes HuR translation | supports the metastasis of colorectal cancer | 63 |
| miR-330 and HuR | regulates STAT3 translation | cachexia | 64 |
| miR-17-19b and HuR | regulates the translation of MYC | ensure the optimal growth of B-cell lymphoma | 65 |
| LncRNA | |||
| lncRNA-GMAN | promotes ephrin A1 translation | enhances the invasion ability of gastric cancer | 70 |
| lncRNA-GMAN | regulates BCL-2, BCL-6, XIAP, e-cadherin, n-cadherin, vimentin, and snail translation | promotes the development of liver cancer | 71 |
| lncRNA-MALAT1 | increases TCF7L2 translation | promotes aerobic glycolysis in liver cancer | 72 |
| LncNB1 | promotes E2F1 translation | induces neuroblastoma cell proliferation and survival. | 73 |
| RP1-5O6.5 (RP1) | attenuates p27kip1 translation | promotes breast cancer cell proliferation and metastasis | 74 |
| PYCARD-AS1 | regulates PYCARD translation | antiapoptosis of breast cancer | 75 |
| Protein | Cancer | Ref. | |
|---|---|---|---|
| LncRNA and RBP | |||
| OCC-1 and HuR | regulates the translation of HuR targets | colorectal cancer | 76 |
| 7SL and HuR | attenuates P53 translation | HeLa | 77 |
| lincRNA-p21 and HuR | regulates the translation of JUNB and CTNNB1 | cervical carcinoma | 78 |
| lncRNA-TRMP and PTBP1 | regulates P27 translation | A549 cell | 79,80 |
| AFAP1-AS1 and AUF1 | promote translation of ERBB2 | breast cancer | 81 |
| Lnc-LBCS and hnRNPK | regulates AR translation | prostate cancer | 82 |
| lncRNA-HITT and YB-1 | regulates HIF-1α translation | colon cancer | 83 |
| LncRNA and microRNA | |||
| LINC00460 and miR-149-5p | regulates CUL4A translation | colorectal cancer | 84 |
| LINC00346 and miR-34a-5p | regulates the translation of CD44, NOTCH1, and AXL proteins | gastric cancer | 85 |
| HOXA11-AS and miR-1297 | regulates EZH2 protein translation | gastric cancer | 86 |
| lncRNA H19 and miR-29b-3p | regulates MCL-1 translation | myeloma | 87 |
| circRNA | |||
| circβ-catenin | generates a new 370 amino acid β-catenin isoform | liver cancer | 90 |
| Circ-FBXW7 | encodes a new 21-kDa protein called FBXW7-185aa | gliomas | 91 |
| circ-SHPRH | translates a new 17 kDa protein, SHPRH-146aa | gliomas | 92 |
| circYap | inhibit the translation of Yap protein | breast cancer | 93 |
| circPABPN1 and HuR | regulates the translation of PABPN1 | Hela | 95 |
| OIP5-AS1 and HuR | regulates target genes of HuR | — | 96 |
| circRNA-MTO1 and TRAF4 | inhibits the translation of Eg5 | breast cancer | 97 |
| circ-MALAT1 and miR-6887-3p | enhances JAK2 expression | liver cancer | 98 |
| circEIF4G2 and miR-218 | increases HOXA1 translation | cervical cancer | 99 |