Table 2.
Basal characteristics of the female subjects with tertiles of FABP4 level at baseline (n = 419).
| Tertiles of FABP4 level | T1 | T2 | T3 | P |
|---|---|---|---|---|
| (6.4–18.4 ng/mL) | (18.4–27.3 ng/mL) | (27.4–85.5 ng/mL) | ||
| n = 139 | n = 140 | n = 140 | ||
| Age (years) | 56 ± 15 | 65 ± 12* | 70 ± 10* | < 0.001 |
| Body mass index | 21.3 ± 3.1 | 23.8 ± 3.0* | 25.9 ± 4.2* | < 0.001 |
| Waist circumference (cm) | 78.2 ± 9.3 | 85.7 ± 9.4* | 92.0 ± 9.4* | < 0.001 |
| Systolic blood pressure (mmHg) | 126 ± 25 | 136 ± 21* | 147 ± 27* | < 0.001 |
| Diastolic blood pressure (mmHg) | 74 ± 13 | 77 ± 12 | 80 ± 13* | 0.001 |
| Pulse rate (beats/min) | 69 ± 12 | 72 ± 12 | 71 ± 9 | 0.321 |
| Smoking habit | 22 (15.8) | 10 (7.1)* | 9 (6.4)* | 0.013 |
| Alcohol drinking habit | 85 (61.2) | 104 (74.3)* | 109 (77.9)* | 0.005 |
| Comorbidity | ||||
| Hypertension | 50 (36.0) | 79 (56.4)* | 94 (67.1)* | < 0.001 |
| Diabetes mellitus | 5 (3.6) | 11 (7.9) | 10 (7.1) | 0.288 |
| Dyslipidemia | 37 (26.6) | 79 (56.4)* | 76 (54.3)* | < 0.001 |
| Biochemical data | ||||
| AST (IU/L) | 21 (18–24) | 23 (19–27)* | 25 (21–30)* | < 0.001 |
| ALT (IU/L) | 15 (13–19) | 19 (14–24)* | 20 (15–26)* | < 0.001 |
| γGTP (IU/L) | 16 (13–22) | 18 (14–27) | 20 (14–28) | 0.103 |
| Blood urea nitrogen (mg/dL) | 13 ± 4 | 15 ± 4* | 16 ± 4* | < 0.001 |
| Creatinine (mg/dL) | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.6* | 0.003 |
| eGFR (ml/min/1.73 m2) | 91.5 ± 19.5 | 83.6 ± 15.7* | 74.1 ± 19.4* | < 0.001 |
| Uric acid (mg/dL) | 4.3 ± 0.9 | 4.7 ± 0.9* | 5.1 ± 1.2* | < 0.001 |
| Total cholesterol (mg/dL) | 199 ± 31 | 212 ± 31* | 212 ± 35* | 0.001 |
| LDL cholesterol (mg/dL) | 116 ± 28 | 127 ± 32* | 129 ± 32* | 0.001 |
| HDL cholesterol (mg/dL) | 67 ± 15 | 63 ± 17* | 61 ± 16* | 0.002 |
| Triglycerides (mg/dL) | 71 (56–100) | 95 (67–122)* | 94 (74–136)* | < 0.001 |
| Fasting glucose (mg/dL) | 92 ± 11 | 98 ± 19* | 100 ± 22* | 0.001 |
| Insulin (µU/ml) | 4.1 (3.0–5.5) | 4.9 (3.7–7.0)* | 5.9 (4.1–8.7)* | < 0.001 |
| HOMA-R | 0.90 (0.67–1.22) | 1.16 (0.80–1.78)* | 1.37 (0.94–2.29)* | < 0.001 |
| Hemoglobin A1c (%) | 4.9 ± 0.4 | 5.2 ± 0.6* | 5.3 ± 0.7* | < 0.001 |
| BNP (pg/mL) | 17 (11–23) | 19 (11–37)* | 23 (14–40)* | 0.003 |
| hsCRP (mg/dL) | 0.02 (0.01–0.05) | 0.04 (0.02–0.08) | 0.05 (0.03–0.10)* | < 0.001 |
Variables are expressed as number (%), means ± SD or medians (interquartile ranges).
AST aspartate transaminase, ALT alanine transaminase, BNP brain natriuretic peptide, eGFR estimated glomerular filtration rate, FABP4 fatty acid-binding protein 4, γGTP γ-glutamyl transpeptidase, HDL high-density lipoprotein, HOMA-R homeostasis model assessment of insulin resistance, hsCRP high-sensitivity C-reactive protein, LDL low-density lipoprotein.
*P < 0.05 versus T1.