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E1181 and T1232 sites of NSD3 in the structure of the NSD3-NCP complex. a, Comparisons of the structural differences between the superimposed NCP-bound wild-type NSD3 (colored in grey) and E1181K-mutated (colored as described above) NSD3. b, The side-chain of Thr1232 in native NSD3 is inserted into a hydrophobic pocket composed of hydrophobic residues from both NSD3 and histone H3.
