Table 1.

Patients aged ≥65 years at diagnosis

Case, gender	Age at diagnosis	Signs and symptoms at diagnosis that first arouse suspicion of acromegaly	Basal GH (μg/L) nadir OGTT	Basal IGF-1 (μg/L)	Basal IGF-1 (ULN)	Adenoma at diagnosis (mm)	Surgery/outcome	Medical treatment last control	Hypopituitarism	Last random GH (μg/L)	Last IGF-1 (μg/L)	Last IGF-1 (ULN)
1, M, 72	65 years	Erectile dysfunction	6.4	447	2.14	9	Yes/remission	n.a.	No	0.73	200	0.97
2, M, 70	65 years	Headache ➔ pituitary incidentaloma	5.9	600	2.87	10	Yes/remission	n.a.	No	0.11	221	0.93
3, F, 80	66 years	Papillary thyroid carcinoma, obstructive sleep apnea syndrome	9.6	695	2.88	23	No	SSA + CAB	?No	4.58	99	0.45
4, F, 72	67 years	Carpal tunnel syndrome, mandibular overgrowth	4.76	752	3.12	11	Yes/remission	n.a.	TSH/ACTH	1.4	209	0.88
5, M, 72	67 years	Mandibular and acral overgrowth, thyroid goiter	1.78	357	1.7	12	?No	SSA	No	4.06	205	0.99
6, F, 75	68 years	Profuse sweating	23	612	2.93	9	Yes/persistence	SSA + GH-RA	No	0.78	220	0.93
7, F, 78	68 years	Papillary thyroid carcinoma, osteoporosis	6.88	1060	4.4	10	No	SSA	No	0.32	161	0.74
8, F, 75	68 years	Carpal tunnel syndrome, acral overgrowth	2.57	314	1.3	10	No	SSA + CAB	No	0.68	152	0.64
9, F, 75	69 years	Obstructive sleep apnea syndrome, mandibular and acral overgrowth	6.36	575	2.39	11	No	SSA	No	0.31	212	0.89
10, F, 82	74 years	Transient ischemic attack ➔ pituitary incidentaloma	25.8	686	2.89	12	No	SSA + CAB	No	9.69	388	1.77
11, F, 94	75 years	Mandibular and acral overgrowth	4	636	2.68	9	No	SSA	No	2.7	233	1.98
12, F, 83	78 years	Mandibular and acral overgrowth	18.7	823	3.76	15	No	SSA	No	2.01	254	1.16
13, M, 88	78 years	Meningioma ➔ pituitary incidentaloma	25.2	570	2.82	9	No	SSA	No	1.96	158	0.78