Fig. 4.

Kaplan–Meier survival curves for OS of HCC patients according to CMTM6 and PD-L1 expression. a OS according to CMTM6 expression status in the whole population, MTM and non-MTM type HCC. b OS according to tumoral PD-L1 expression status in the whole population, MTM and non-MTM type HCC. c OS according to a combination of CMTM6/PDL1 coexpression. Group I: CMTM6Low/PD-L1−; Group II: CMTM6High/PD-L1− or CMTM6Low/PD-L1+; Group III: CMTM6High/PD-L1+. d OS according to new immune classification. Type BI: inflammatory cells positive and both negative (CMTM6Low/PD-L1−); type BII: inflammatory cells positive and single positive (CMTM6High/PD-L1− or CMTM6Low/PD-L1+); type BIII: inflammatory cells positive and both positive (CMTM6High/PD-L1+). PD-L1− PD-L1-negative, PD-L1+ PD-L1-positive