Table 2.
Univariate analyses of prognostic factors correlated with OS in MTM and non-MTM HCC
| Variables | Overall | MTM | Non-MTM | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Overall survival | ||||||
| Age (years)a (< 50 vs. ≥ 50) | 0.886 (0.746–1.053) | 0.169 | 0.828 (0.643–1.067) | 0.144 | 0.833 (0.584–1.189) | 0.315 |
| Gender (male vs. female) | 0.767 (0.578–1.017) | 0.066 | 0.625 (0.391–1.000) | 0.050 | 1.006 (0.794–1.276) | 0.958 |
| HBV (positive vs. negative) | 1.331 (0.948–1.869) | 0.099 | 1.214 (0.741–1.991) | 0.441 | 1.471 (0.922–2.347) | 0.106 |
| AFP (ng/ml) (< 20 vs. ≥ 20) | 1.227 (1.005–1.498) | 0.045 | 1.263 (0.959–1.664) | 0.097 | 1.073 (0.799–1.441) | 0.639 |
| Cirrhosis (no vs. yes) | 1.064 (0.841–1.346) | 0.604 | 1.110 (0.791–1.558) | 0.545 | 1.003 (0.724–1.390) | 0.985 |
| Tumor multiplicity (single vs. multiple) | 1.633 (1.359–1.963) | 0.000 | 1.771 (1.349–2.324) | 0.000 | 1.478 (1.151–1.897) | 0.002 |
| Tumor sizeb (cm) (< 5 vs. ≥ 5) | 1.618 (1.322–1.980) | 0.000 | 1.497 (1.136–1.973) | 0.004 | 1.665 (1.232–2.250) | 0.001 |
| Differentiation (well vs. moderate–poor) | 1.535 (1.143–2.062) | 0.004 | 1.479 (1.007–2.170) | 0.046 | 1.513 (0.949–2.415) | 0.082 |
| TNM stage (I–II vs. III–IV) | 1.778 (1.491–2.120) | 0.000 | 1.874 (1.446–2.429) | 0.000 | 1.640 (1.290–2.086) | 0.000 |
| Vascular invasion (no vs. yes) | 2.452 (1.952–3.081) | 0.000 | 3.472 (2.362–5.103) | 0.000 | 1.901 (1.427–2.532) | 0.000 |
| Tumor capsule (complete vs. incomplete) | 0.746 (0.627–0.889) | 0.001 | 0.657 (0.510–0.846) | 0.001 | 0.886 (0.696–1.130) | 0.330 |
| LN metastasis (no vs. yes) | 2.619 (1.817–3.775) | 0.000 | 4.290 (2.524–7.292) | 0.000 | 1.754 (1.056–2.912) | 0.030 |
| Cytological type (liver cell vs. clear cell vs. fatty-rich vs. giant cell) | 0.983 (0.860–1.124) | 0.799 | 1.062 (0.877–1.285) | 0.538 | 0.897 (0.733–1.096) | 0.288 |
| Tumoral PD-L1 (− vs. +) | 1.217 (1.021–1.452) | 0.029 | 1.610 (1.247–2.102) | 0.000 | 0.899 (0.706–1.144) | 0.386 |
| Inflammatory cell PD-L1 (− vs. +) | 1.161 (0.978–1.379) | 0.089 | 1.458 (1.135–1.875) | 0.003 | 0.926 (0.729–1.175) | 0.526 |
| Inflammatory cells (low vs. high) | 1.038 (0.872–1.235) | 0.676 | 1.198 (0.931–1.542) | 0.160 | 0.855 (0.671–1.089) | 0.206 |
| CMTM6 expression (low vs. high) | 1.493 (1.250–1.783) | 0.000 | 1.574 (1.221–2.028) | 0.000 | 1.310 (1.019–1.684) | 0.035 |
AFP a-fetoprotein, HBV hepatitis B virus infection, LN lymph node, HR hazard ratio, CI confidence interval
*P value < 0.05 in bold are statistically significant
aMedian age; bMedian tumor size