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. 2020 Aug 17;70(2):453–461. doi: 10.1007/s00262-020-02648-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Distribution of PD-L1⁺ CSCs and CD4⁺ T cells in NSCLC patients depending on the best overall response. a Frequency of PD-L1⁺ CSCs differs in patients with PD vs. SD vs. PR. *p = 0.0014 95% CI for difference: (2.85%, 7.82%) vs. (1.13%, 7.11%) vs. (0.39%, 1.90%). b Frequency of CD4 T cells in patients with PD vs. SD vs. PR. *p = 0.0453 95% CI for difference: (38.38%, 56.31%) vs. (48.45%, 64.2%) vs. (52.55%, 69.14%). c Frequency of PD-1⁺ CD4⁺ T cells in patients with PD vs. SD vs. PR. *p = 0.0099 95% CI for difference: (48.40%, 68.74%) vs. (7.45%, 70.89%) vs. (11.98%, 44.79%). d Frequency of Tim-3⁺ CD4⁺ T cells in patients with PD vs. SD vs. PR. *p = 0.0125 95% CI for difference: (11.65%, 26.38%) vs. (2.81%, 10.59%) vs. (0.77%, 13.89%)