Table 3.

Event rate analysis

HPI range	Event rate (95% CI), %	Median time to event (95% CI), min	25th percentile time to event (95% CI), min	75th percentile time to event (95% CI), min	Number of samples
Combined (N = 305)
0–9	9.9 [8.6, 11.3]	9.7 [8.7, 10.3]	6.3 [5.7, 7.0]	12.3 [12.0, 13.0]	5715/57,983
10–19	17.5 [15.4, 19.7]	9.0 [8.3, 10.0]	6.0 [5.3, 6.7]	12.7 [12.0, 13.0]	5689/32,581
20–29	27.4 [24.8, 30.3]	8.7 [8.0, 9.0]	5.3 [4.7, 6.0]	11.7 [11.3, 12.3]	6882/25,082
30–39	41.3 [38.0, 44.8]	8.3 [8.0, 8.7]	5.3 [5.0, 5.7]	11.3 [11.0, 12.0]	9635/23,286
40–49	54.7 [50.9, 58.4]	7.4 [7.0, 8.1]	4.7 [4.0, 5.0]	10.7 [10.0, 11.0]	5562/10,182
50–59	61.7 [57.6, 65.5]	7.3 [6.7, 7.7]	4.3 [4.0, 5.0]	11.0 [10.0, 11.7]	3843/6239
60–69	67.1 [62.9, 71.1]	6.7 [6.0, 7.7]	3.7 [3.3, 4.1]	11.0 [10.0, 12.0]	3601/5382
70–79	74.1 [70.0, 78.1]	6.7 [5.7, 7.3]	3.7 [3.3, 4.3]	10.3 [9.7, 11.0]	3396/4598
80–89	79.9 [75.9, 83.6]	6.0 [5.3, 6.7]	3.3 [3.0, 3.7]	9.7 [9.0, 10.3]	4091/5127
90–99	89.2 [86.3, 92.1]	2.7 [2.3, 3.0]	1.0 [1.0, 1.0]	6.7 [6.0, 7.3]	14,007/15,726
100	100 [100, 100]	0 [0, 0]	0 [0, 0]	0 [0, 0]	5690/5728
Blinded arm (N = 150)
0–9	9.9 [8.2, 11.9]	9.7 [8.3, 10.7]	6.3 [6.0, 7.0]	12.3 [11.7, 13.0]	2899/29,445
10–19	16.5 [13.5, 20.0]	9 [7.7, 10.1]	5.7 [5.0, 6.7]	12.7 [11.3, 13.3]	2616/15,875
20–29	25.1 [21.8, 28.8]	8.7 [7.7, 9.3]	5.3 [4.3, 6.1]	12.0 [11.3, 12.3]	2929/11,651
30–39	40.0 [35.2, 44.7]	8.3 [7.7, 9.0]	5.3 [5.0, 5.7]	11.3 [10.7, 12.0]	4540/11,392
40–49	54.0 [48.2, 59.6]	7.3 [6.7, 8.3]	4.3 [4.0, 5.0]	10.3 [9.8, 11.3]	2490/4625
50–59	63.8 [58.6, 69.3]	7.7 [6.7, 8.7]	4.3 [3.7, 5.3]	11.3 [10.0, 12.0]	1749/2742
60–69	68.7 [63.9, 74.1]	7.7 [6.3, 8.3]	3.7 [3.3, 4.7]	11.3 [10.3, 12.3]	1623/2357
70–79	74.6 [69.3, 80.2]	6.7 [6.0, 8.0]	3.7 [3.0, 4.7]	10.7 [9.3, 11.3]	1578/2116
80–89	79.7 [73.0, 85.9]	6.3 [5.3, 7.3]	3.3 [3.0, 4.0]	10.0 [8.8, 11.0]	1842/2317
90–99	90.2 [86.3, 93.8]	2.7 [2.3, 3.0]	1 [1.0, 1.3]	6.7 [6.0, 7.7]	6786/7536
100	100 [100, 100]	0 [0, 0]	0 [0, 0]	0 [0, 0]	3292/3292
Unblinded arm (N = 155)
0–9	9.9 [8.1, 11.9]	9.3 [8.0, 10.7]	6.0 [4.8, 7.3]	12.3 [11.7, 13.3]	2828/28,512
10–19	18.5 [15.6, 21.4]	9.0 [8.0, 10.7]	6.0 [5.3, 7.3]	12.3 [11.7, 13.0]	3073/16,696
20–29	29.6 [25.2, 33.9]	8.3 [7.7, 9.5]	5.7 [4.7, 6.3]	11.7 [10.7, 12.3]	3947/13,404
30–39	43.1 [38.4, 47.5]	8.3 [7.7, 9.0]	5.2 [4.3, 5.7]	11.6 [11.0, 12.3]	5068/11,819
40–49	55.5 [50.7, 60.3]	7.7 [6.7, 8.7]	4.7 [4.0, 5.3]	10.7 [10.0, 11.3]	3064/5524
50–59	60.2 [53.9, 66.0]	7.0 [6.0, 7.8]	4.3 [4.1, 5.0]	10.7 [9.6, 11.7]	2087/3466
60–69	66.0 [59.7, 72.4]	6.0 [5.3, 7.3]	3.3 [3.0, 4.3]	10.3 [8.7, 12.0]	1974/2991
70–79	73.9 [68.4, 79.5]	6.5 [5.3, 7.7]	3.7 [3.0, 4.0]	10.0 [9.0, 11.0]	1815/2459
80–89	80.1 [75.3, 85.3]	6.0 [5.0, 6.7]	3.3 [2.7, 4.0]	9.3 [8.0, 10.3]	2238/2794
90–99	88.5 [83.9, 92.6]	2.7 [2.3, 3.0]	1.0 [1.0, 1.0]	6.3 [5.0, 7.3]	7232/8179
100	100 [100, 100]	0 [0, 0]	0 [0, 0]	0 [0, 0]	2425/2425

HPI Hypotension Prediction Index