Table 2.
Clinical features of different histopathological types of MPO-ANCA-GN.
| Focal (n = 32) | Mixed (n = 26) | Crescentic (n = 29) | Sclerotic (n = 25) | p | |
|---|---|---|---|---|---|
| Male (n, %) | 17 (53.1%) | 12 (46.2%) | 15 (51.7%) | 12 (48.0%) | 0.95 |
| Age(years) | 65.0 (49.5, 71.8) | 64.3±10.2 | 64.0 (53.0, 66.5) | 66.0 (55.5, 73.5) | 0.676 |
| Duration of renal disease (months) | 2.0 (1.0, 3.0) | 1.0 (0.95, 3.0) | 1.0 (1.0, 2.0) | 1.0 (1.0, 4.5) | 0.508 |
| BVAS at diagnosis | 17.7 ± 3.6 | 18.0 (18.0, 21.3) | 19.1 ± 2.8 | 18.0 (17.0, 19.0) | 0.172 |
| Initial RRT (n, %) | 4 (12.5%) | 13 (50.0%) b | 13 (44.8%) b | 17 (68.0%) b | <0.001 |
| DFPP (n, %) | 2 (6.3%) | 6 (23.1%) | 7 (24.1%) | 8 (32.0%) | 0.096 |
| Serum Creatinine (μmol/L) | 157.2 (85.5, 229.1) | 306.1 (185.2, 666.7) b | 430.6 (211.3.2, 670.0) a | 557.5 ± 306.6 a | <0.001 |
| eGFR (mL/min/1.73m2) | 41.3 (27.8, 94.8) | 18.6 (7.2, 34.7) b | 12.1 (6.6, 28.7) a | 8.9 (5.4, 17.7) a | <0.001 |
| CRP (mg/L) | 76.4 (16.4, 119.8) | 27.9 (14.7, 71.2) | 49.9 (14.9, 104.3) | 26.8 (5.7, 76.4) | 0.098 |
| RF (IU/mL) | 29.9 (10.6, 152.5) | 12.5 (10.7, 36.7) | 11.1 (10.1, 31.9) c | 10.1 (9.5, 11.0) a | 0.004 |
| Serum Albumin (g/L) | 29.7 ± 8.2 | 29.7 ± 4.3 | 28.1 ± 4.3 | 28.3 ± 4.8 | 0.543 |
| Hemoglobin (g/L) | 91.3 ± 19.4 | 88.0 ± 23.9 | 76.0 (67.5, 88.0) b | 79.0 (68.0, 82.0) | 0.034 |
| Urine red blood cell (/μL) | 96.3 (27.0, 207.6) | 230.0 (107.7, 1087.8) | 358.9 (61.7, 929.7) b | 297.2 (114.8, 648.7) b | 0.014 |
| urine protein (g/24h) | 0.92 (0.58, 1.67) | 1.18 (0.56, 4.40) | 1.63 (1.05, 2.57) | 1.55 (0.44, 2.78) | 0.312 |
| Extrarenal involvement (n, %) | |||||
| Lung | 16 (50.0) | 14 (53.8) | 17 (58.6) | 14 (56.0) | 0.922 |
| ENT | 7 (21.9) | 12 (46.2) | 11 (37.9) | 9 (36.0) | 0.264 |
| Skin | 3 (9.4) | 5 (19.2) | 4 (13.8) | 3 (12.0) | 0.740 |
| Abdominal | 3 (9.4) | 2 (7.7) | 0 | 1 (4.0) | 0.387 |
| Fever | 4 (12.5) | 5 (19.2) | 3 (10.3) | 6 (24.0) | 0.500 |
a
Focal versus mixed, crescentic, and sclerotic (p < 0.01).
b
Focal versus mixed, crescentic, and sclerotic (p < 0.05).
c
Mixed versus crescentic and sclerotic (p < 0.05).