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. 2021 Feb 4;8:622103. doi: 10.3389/fcell.2020.622103

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Copyright © 2021 Tong, Dong, Cui, Jiang, Jin and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Domain diversity of Cas12a, Cas12b, and Cas12e and type V-K CRISPR loci. (A) The REC lobes of Cas12a, Cas12b, and Cas12e all contain two REC domains. There are some differences in the NUC lobe, including the presence of the PI domain and the additional NTSB domain of Cas12e. (B) Transposon-related genes and CRISPR elements are located at both ends of the transposon.