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. 2021 Feb 17;11:3962. doi: 10.1038/s41598-021-83352-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characteristic features of UV induced mutation are observed only in patients with cutaneous T-cell lymphoma. Whole genome sequencing data from the UK 100,000 genomes project comparing representative cutaneous and nodal T-cell lymphoma patients. The highlighted track on the circos plots is a rainfall diagram of SNVs where distance from the centre is proportional to the logarithm of the distance between adjacent SNVs. Cutaneous T-cell lymphoma patients have a characteristic inner ring of C>T variants due to CC>TT substitutions, which are also clear in the light green bar on the dinucleotide variants plot. Single nucleotide variants occurring within gene bodies were assessed to determine whether they affect the transcriptional or non-transcriptional strand. Significant transcriptional strand bias was observed for C>T mutations in cutaneous T-cell lymphoma but not nodal T-cell lymphoma indicating transcription-coupled nucleotide excision repair, a feature of UV induced mutation.