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. 2021 Feb 17;12:1076. doi: 10.1038/s41467-021-21394-y

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© The Author(s) 2021, corrected publication 2021

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Fig. 4 — The branch length score (BLS) of the coding region of a uORF is significantly lower than that of the start codon of that uORF in humans (a) and flies (b). c Example of a typical uORF with a conserved start codon in the fly smg gene. The orthologous peptide sequences in distant lineages exhibit many nonsynonymous substitutions and are frequently disrupted by stop codons (*) or frameshifts (!). d Relationship between the length and the BLS of uORF peptides in humans and flies. The uORFs were grouped into custom bins of increasing peptide length. The median peptide length and BLS value of each bin are displayed and were used to calculate Spearman’s correlations (ρ) with two-sided P values. “AA” refers to amino acid. Source data are provided as a Source Data file.