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. 2021 Feb 17;11:4019. doi: 10.1038/s41598-021-83249-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between maternal prenatal anxiety and amygdala functional connectivity controlling for postpartum depression and anxiety. A correlation analysis between second trimester SCL-90-R scores and left amygdala functional connectivity controlling for postnatal anxiety (SCL-90-R) and depression (EPDS), in addition to child’s age, sex, birth weight, gestational age at birth, household income and prenatal depressive symptoms was performed. Second trimester SCL-90-R scores were negatively correlated with functional connectivity between the left amygdala and two clusters in the left and right parietal regions both shown in blue. The data plotted are residuals of anxiety scores and cluster-averaged left amygdala functional connectivity after accounting for covariates. Prenatal anxiety scores and connectivity between the left amygdala and the left parietal region is plotted on the left (Cluster size: 2275 voxels; rho = − 0.51, p = 1.8 × 10^–4; Peak: − 46, − 17, 39—left postcentral gyrus) while connectivity between the left amygdala and right parietal region is plotted on the right (Cluster size: 2155 voxels; rho = − 0.52, p = 1.1 × 10^–4; Peak: 50, − 11, 30—right postcentral gyrus). Results were corrected for multiple comparisons at voxelwise and cluster p < 0.05 (n = 50).