Table 2.
Univariate and multivariate analyses of cancer special survival (CSS) and overall survival (OS) for 4595 patients with intrahepatic cholangiocarcinoma.
| Variables | CSS | OS | ||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||
| P value | HR (95% CI) | P value | P value | HR (95% CI) | P value | |
| Age | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| < 65 | Reference | Reference | ||||
| ≥ 65 | 1.175 (1.100, 1.254) | 1.202 (1.127, 1.282) | ||||
| Sex | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| Female | Reference | Reference | ||||
| Male | 1.184 (1.110, 1.264) | 1.200 (1.126, 1.279) | ||||
| Race | 0.144 | 0.048 | 0.078 | 0.034 | ||
| Black | Reference | Reference | ||||
| White | 0.928 (0.827, 1.041) | 0.200 | 0.913 (0.816, 1.021) | 0.110 | ||
| API/AI | 0.846 (0.736, 0.972) | 0.019 | 0.838 (0.732, 0.960) | 0.011 | ||
| Marital status | < 0.001 | 0.003 | < 0.001 | 0.003 | ||
| Unmarried | Reference | Reference | ||||
| Married | 0.904 (0.846, 0.967) | 0.906 (0.848, 0.968) | ||||
| Insured status | < 0.001 | 0.053 | < 0.001 | 0.055 | ||
| Uninsured/unknown | Reference | Reference | ||||
| Any medicaid/insured | 0.888 (0.787, 1.002) | 0.891 (0.792, 1.003) | ||||
| Year at diagnosis | 0.006 | 0.001 | 0.001 | < 0.001 | ||
| 2004–2007 | Reference | Reference | ||||
| 2008–2011 | 1.161 (1.029, 1.310) | 0.015 | 1.162 (1.032, 1.307) | 0.013 | ||
| 2012–2015 | 1.022 (0.908, 1.152) | 0.717 | 1.008 (0.897, 1.133) | 0.893 | ||
| Grade | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| Grade I/II | Reference | Reference | ||||
| Grade III/IV | 1.411 (1.277, 1.558) | < 0.001 | 1.397 (1.268, 1.540) | < 0.001 | ||
| Unknown | 1.199 (1.101, 1.305) | < 0.001 | 1.187 (1.092, 1.290) | < 0.001 | ||
| Tumor size | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| < 5 cm | Reference | Reference | ||||
| ≥ 5 cm | 1.115 (1.019, 1.219) | 0.018 | 1.086 (0.995, 1.184) | 0.065 | ||
| Unknown | 1.252 (1.137, 1.378) | < 0.001 | 1.227 (1.117, 1.347) | |||
| AJCC stage | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| I | Reference | Reference | ||||
| II | 1.452 (1.236, 1.706) | < 0.001 | 1.395 (1.194, 1.631) | < 0.001 | ||
| III | 1.939 (1.740, 2.162) | < 0.001 | 1.849 (1.665, 2.053) | < 0.001 | ||
| IV | 2.585 (2.322, 2.877) | < 0.001 | 2.470 (2.227, 2.738) | < 0.001 | ||
| Surgery | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| No surgery | Reference | Reference | ||||
| Local tumor excision/segmental resection | 0.322 (0.282, 0.369) | < 0.001 | 0.330 (0.290, 0.376) | < 0.001 | ||
| Lobectomy/hepatectomy | 0.295 (0.268, 0.339) | < 0.001 | 0.295 (0.259, 0.337) | < 0.001 | ||
| Chemotherapy | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| No/unknown | Reference | Reference | ||||
| Yes | 0.425 (0.396, 0.456) | 0.417 (0.389, 0.447) | ||||
| Radiotherapy | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| No/unknown | Reference | Reference | ||||
| Yes | 0.819 (0.748, 0.897) | 0.811 (0.741, 0.887) | ||||
API/AI American Indian/AK Native, Asian/Pacific Islander, CSS cancer‐specific survival, OS overall survival.