Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 17;11:4030. doi: 10.1038/s41598-021-83612-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Pembrolizumab increases IFNγ and IL-10 levels in co-cultures of CD4⁺ T cells and allogeneic dendritic cells. Ability of pembrolizumab (anti-PD-1; 1.0 μg/ml) to modify IFNγ (A,D) or IL-10 (B,E) levels in co-cultures of CD4⁺ T cells and allogeneic immature (A–C) or mature (D–F) dendritic cells relative to isotype control. (A,B,D,E) indicate responses of individual donors (each colour represents an individual donor), (C,F) show percentage change in response in the presence of pembrolizumab relative to isotype control (mean + SEM, n = 8). (G) Shows impact of pembrolizumab upon CD4⁺ T cell proliferation in the presence of allogeneic immature or mature dendritic cells. Data presented as percentage change relative to isotype (mean + SEM, n = 8). The impact of pembrolizumab was statistically significant compared to isotype control (* one sample T-test or ^ one sample Wilcoxon test). There was a significant difference between IFNγ and IL-10 (+ 2-tailed T-test).